Linked Life Data

7085258

Source:http://linkedlifedata.com/resource/pubmed/id/7085258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-8-26
pubmed:abstractText
An intravenous injection of endotoxin into BALB/c mice bearing subcutaneous Meth A sarcomata caused hemorrhagic necrosis and reduced growth of the tumors. In a number of instances this was followed by regression. alpha-Adrenergic blockade with phentolamine prior to endotoxin did not influence tumor growth, but tended to reduce the incidence of regression when compared to mice merely treated with endotoxin. The frequency of hemorrhagic necrosis was not changed, although the extent of necrosis was somewhat reduced. The alpha-adrenoceptor blocking agent phenoxybenzamine nullified the growth retardation induced by endotoxin and reduced the frequency of regression. Moreover both incidence and extent of necrosis were diminished. Beta-adrenoceptor blockade with propranolol seems to potentiate the effect of endotoxin on tumor growth in the highest dose, but had no substantial effect on the necrotizing activities of endotoxin. Both alpha-blocking agents impaired induction of hemorrhagic necrosis and nullified tumor growth inhibition by tumor necrosis serum (TNS). beta-Adrenoceptor blockade decreased only the incidence of necrosis induced by TNS. Regressing tumors had considerably more hemorrhagic necrosis irrespective of pretreatment, excepted phenoxybenzamine. A single injection of the latter agent caused a dose-dependent stimulation of tumor growth, while the other agents exerted no effect. It is suggested that both normal and endotoxin-modified tumor growth are under alpha-adrenergic control and that induction of hemorrhagic necrosis is possibly mediated by release of adrenal catecholamines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-71
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of adrenoceptor blockade on hemorrhagic necrosis of meth A sarcomata induced by endotoxin or tumor necrosis serum.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't