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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1982-7-19
|
| pubmed:abstractText |
Electrolyte concentrations in the erythrocytes, serum and 24-hr urine were measured in 34 untreated essential hypertensives (EH), 32 normotensives with a family history of hypertension (N+), 112 normotensives without a family history of hypertension (N-), 76 senior high school students with high blood pressure (H) and 110 students with normal blood pressure (C). For the measurement of intra-erythrocyte electrolytes, a new method to decrease the trapped plasma was developed and adopted. A new simple method to collect 24-hr urine was devised, too. The results were as follows: 1) The sodium concentration [Na] and the ratio of [Na] to potassium concentration [Na/K] in the erythrocytes were significantly higher in the EH and N+ than in the group of N- (p less than 0.01). 2) There was a positive correlation (r = 0.43) between the [Na/K] in the serum and erythrocytes in the 3 groups. The [Na/K] value in the erythrocytes to a given [Na/K] value in the serum was higher in EH than in the group of N-. 3) When the group of H was compared with C, the Na excretion of the 24-hr urine in the former group was found to be slightly higher, and the [Na/K] of the 24-hr urine and the [Na] and [Na/K] values of the erythrocytes were significantly higher, too. It may therefore be said that an increase in the intracellular [Na] or [Na/K], which may be caused genetically, and an excess of Na intake and an increase of the ratio of Na/K intake are presumed to play an important role in the pathogenesis of essential hypertension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0047-1828
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
512-22
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7077814-Adolescent,
pubmed-meshheading:7077814-Adult,
pubmed-meshheading:7077814-Blood Pressure,
pubmed-meshheading:7077814-Blood Specimen Collection,
pubmed-meshheading:7077814-Electrolytes,
pubmed-meshheading:7077814-Erythrocytes,
pubmed-meshheading:7077814-Humans,
pubmed-meshheading:7077814-Hypertension,
pubmed-meshheading:7077814-Middle Aged,
pubmed-meshheading:7077814-Potassium,
pubmed-meshheading:7077814-Sodium,
pubmed-meshheading:7077814-Time Factors
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Cation imbalance in erythrocytes, serum and 24-hour urine from patients with essential hypertension and adolescents with high blood pressure.
|
| pubmed:publicationType |
Journal Article
|