Linked Life Data

7070967

Source:http://linkedlifedata.com/resource/pubmed/id/7070967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-6-21
pubmed:abstractText
Voltage clamp analysis of the transient outward (positive dynamic) current was performed in sheep Purkinje fibers at a pulse frequency of 1/min. 4-aminopyridine (4-AP, 1 mM) suppressed most of the transient outward current, thus revealing the slow inward current, isi, and an associated brief outward current ibo. The long lasting component of the current suppressed by 4-AP was labelled ilo. In the presence of 4-AP, ibo was suppressed either by caffeine 10 mM or when Sr was substituted for Ca, both conditions making isi clearly detectable. Mn ions suppressed both isi and ibo. Current decay was a monoexponential process for ibo (tau = 12 ms) and a two exponential process for ilo (tau 1 = 80-100 ms, tau 2 = 250-400 ms). The peak amplitude-Em relationships were different for the two currents. It was shown that the reversal potential of ilo was not measurable by the usual method probably because of the too fast activation-deactivation kinetics of the current. It is concluded that not one but two transient outward currents with different electrophysiological and pharmacological characteristics exist in the sheep Purkinje fiber. The reason of the caffeine-sensitivity of ibo is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
392
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
352-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Existence of two transient outward currents in sheep cardiac Purkinje fibers.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't