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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1982-5-21
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pubmed:abstractText |
The pharmacokinetic parameters of sulfamethoxazole and trimethoprim were measured in 12 newborn infants of less than 3 days postnatal age, following a single or repeated intravenous injection. The mean half-lives for SMZ and TMP were 16.5 hours and 19.0 hours, respectively. The mean volumes of distribution were SMZ 0.48 L/kg and TMP 2.7 L/kg. The mean drug clearances were SMZ 0.65 ml/minute and TMP 3.31 ml/minute. From these data the recommended loading dose is SMZ 10 mg/kg with TMP 3 mg/kg, and the maintenance dose is SMZ 3 mg/kg with TMP 1 mg/kg twice daily. No adverse side effects were seen during treatment, and the bilirubin-binding capacity of albumin were not changed at therapeutic concentrations of the antimicrobial drugs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-3476
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-50
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7062219-Drug Therapy, Combination,
pubmed-meshheading:7062219-Half-Life,
pubmed-meshheading:7062219-Humans,
pubmed-meshheading:7062219-Infant, Newborn,
pubmed-meshheading:7062219-Infant, Newborn, Diseases,
pubmed-meshheading:7062219-Injections, Intravenous,
pubmed-meshheading:7062219-Kinetics,
pubmed-meshheading:7062219-Klebsiella Infections,
pubmed-meshheading:7062219-Metabolic Clearance Rate,
pubmed-meshheading:7062219-Sulfamethoxazole,
pubmed-meshheading:7062219-Trimethoprim
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pubmed:year |
1982
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pubmed:articleTitle |
Pharmacology of trimethoprim-sulfamethoxazole in newborn infants.
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pubmed:publicationType |
Journal Article
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