Linked Life Data

7061861

Source:http://linkedlifedata.com/resource/pubmed/id/7061861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-5-27
pubmed:abstractText
Murine alveolar and peritoneal macrophages (AM phi, PM phi) and M phi-like cultured cell lines were analyzed for IgE Fc receptors by rosette formation with mouse IgE-sensitized red cells and by binding of radiolabeled mouse IgE. A mean of 90.4% AM phi, 56.9% PM phi, 93.4% P388D1, 81.2% J774.1, 15.6% WEHI3, 54.7% WR19M.1, 52.3% RAW264.7, and 19.5% RAW309Cr.1 M phi-like cells formed IgE rosettes. The rosettes were specific for native mouse IgE and were inhibited by mouse IgE but not mouse IgG, IgA, IgM, or heat-denatured mouse IgE. Rat IgE, but not human IgE, induced rosettes and inhibited mouse IgE rosettes. Trypsin treatment of the M phi abolished IgE rosette formation. Mouse IgE bound to P388D1 M phi-like cells with a KA of 7.6 +/- 0.2 X 10(6) M-1 to 3.3 +/- 0.9 X 10(5) binding sites. After 30 min of incubation at 37 degrees C, 30 to 45% of AM phi, P388D1, and J774.1 M phi-like cells ingested erythrocytes sensitized with IgE but not unsensitized erythrocytes. The data indicate that mouse M phi bear Fc receptors specific for IgE that mediate phagocytosis of IgE-sensitized erythrocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2265-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Fc receptors for IgE on mouse macrophages and macrophage-like cell lines.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't