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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1982-4-22
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pubmed:abstractText |
Cyclophosphamide administered intraperitoneally to mice at a dose of 100 mg/kg caused a dose related increase in urinary bladder weight within 48 hours of treatment. Disulfiram effectively prevented cyclophosphamide-induced increase in bladder weight when disulfiram was administered by either the oral or intraperitoneal route. Disulfiram (125 mg/kg) was most effective when given within one hour of cyclophosphamide treatment. These results suggest that disulfiram, unlike other putative protectants, is effective when administered orally.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0034-5164
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7058285-Animals,
pubmed-meshheading:7058285-Cyclophosphamide,
pubmed-meshheading:7058285-Cystitis,
pubmed-meshheading:7058285-Disulfiram,
pubmed-meshheading:7058285-Male,
pubmed-meshheading:7058285-Mice,
pubmed-meshheading:7058285-Organ Size,
pubmed-meshheading:7058285-Urinary Bladder
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pubmed:year |
1982
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pubmed:articleTitle |
The prevention of cyclophosphamide-induced cystitis in mice by disulfiram.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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