Linked Life Data

7056475

Source:http://linkedlifedata.com/resource/pubmed/id/7056475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-4-20
pubmed:abstractText
The uptake of indoleamines into the retina of rats, rabbits, cows, pigs, baboons. Cynomolgus monkeys, and man was studied by fluorescence microscopy and autoradiography. Indoleamines were either injected intravitreally or the retinas were incubated with them. Fluorescence microscopy failed to show any indoleamine accumulating neurons in all species investigated except rabbit, confirming previous observations. However, autoradiography showed uptake in a distinct class of neurons in cows and pigs. These neurons had their cell bodies among the amacrine cells and most of their processes branched in the middle of the inner plexiform layer. This is in contradistinction to the dopaminergic neurons, which in cows and pigs have all their processes in the outermost sublamina of the inner plexiform layer. The fluorescence microscopy is quite sensitive to small variations in the indoleamine molecule. The discrepancy between the results with fluorescence microscopy and autoradiography therefore suggest that there is an active uptake mechanism for indoleamines in cows and pigs but that the substances are rapidly transformed to compounds not possible to detect in the fluorescence microscope. No specific indoleamine accumulating mechanism was detected in the retina of rats, baboons, cynomolgus monkeys, or man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0721-832X
pubmed:author
pubmed:issnType
Print
pubmed:volume
218
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Autoradiography of (3H)-5-hydroxytryptamine uptake in the retina of some mammals.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't