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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1982-3-13
|
| pubmed:abstractText |
The hydrophobicity and charge of the cell surface of M protein-positive (M+) and the less virulent M protein-negative (M-) strains of type 12 Streptococcus pyogenes have been studied, respectively, by hydrophobic interaction chromatography and free zone electrophoresis. The M+ strain had a more hydrophobic and a more negatively charged surface than the M- strain. When the M+ strain was cultivated in the presence of sub-minimum inhibitory concentrations of different antibiotics, its hydrophobicity either decreased or did not change. The M+ organisms adhered to pharyngeal epithelial cells more avidly than M+; however, cultivation of both strains with sub-minimum inhibitory concentrations of penicillin and rifampin led to the decrease in adhesion. Tetracycline caused a decrease in adhesion for the M+ strain only, whereas cephalothin and polymyxin (to which the strains are resistant) did not affect adhesion or hydrophobicity of the M+ organisms. The negative surface charge of the M+ bacteria increased considerably upon exposure to rifampin and penicillin, and the M- bacteria exhibited small or no change. The contributions of these changes to suppression of infections are discussed.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-13954539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-346604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-390065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-396637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-396638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-40528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-4208204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-4325956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-4587386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-6991471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7034640-768404
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0066-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
563-6
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1981
|
| pubmed:articleTitle |
Effect of subinhibitory concentrations of antibiotics on the adhesion of Streptococcus pyogenes to pharyngeal epithelial cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|