Linked Life Data

7020185

Source:http://linkedlifedata.com/resource/pubmed/id/7020185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-9-25
pubmed:abstractText
Malaria infection is characterized by extensive destruction of erythrocytes. In addition, the surface membrane of parasitized erythrocytes becomes biochemically and antigenically modified. Thus during infection the host immune system is exposed to massive amounts of modified erythrocytes on a scale not normally considered in conventional immunological experiments. The haemocytoxic drug phenylhydrazine hydrochloride has been used to mimic, in otherwise normal animals, the effect of the modification and destruction of erythrocytes which occurs in malaria. The experiments demonstrated that protective immunity to Plasmodium berghei KSP11 infection in rats and mice is significantly enhanced by this treatment, that this effect generates memory, can be transferred with spleen cells, and can have both enhancing and suppressive action on the protective immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0303-4208
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Erythrocyte destruction and protective immunity to Malaria: enhancement of the immune response by phenylhydrazine treatment.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't