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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1981-9-15
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pubmed:abstractText |
The ability of suppressor cells induced by the intravenous administration of 4-hydro-3-nitrophenyl acetyl (NP)-modified syngeneic cells to reduce an idiotypic B cell response was studied in both an in vivo and an in vitro system. Idiotype-positive B cells were assayed by the ability of guinea pig anti-idiotypic antiserum to specifically inhibit idiotype-positive plaque formation. It was found that up to 57% of the PFC response in vivo and 100% of the PFC response in vitro was inhibitable with antiidiotypic antiserum. The expression of these idiotype-positive B cells could be suppressed by the transfer of spleen cells form mice treated 7 d previously with NP coupled syngeneic cels. T cells are both required and sufficient for the transfer of idiotype specific suppression. The induction of these idiotype-specific T suppressor cells directly with antigen suggests that recognition of unique determinants on cell surfaces is important for regulation of lymphoid cell interactions. The role of idiotype-specific suppressor cells in the network of lymphoid interactions is discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-107261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-1082920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-1091706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-115960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-15036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-159936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-308883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-325170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-365545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-365546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-4114394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-4139230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-4403565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-5417388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6034749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6156980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6157748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-61874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-62017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6444660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6445398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6445931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-658116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-690432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-6966320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-806463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-85681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-87484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-91656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-92517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7019373-93548
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
640-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7019373-Animals,
pubmed-meshheading:7019373-Antibody Specificity,
pubmed-meshheading:7019373-Antibody-Producing Cells,
pubmed-meshheading:7019373-Female,
pubmed-meshheading:7019373-Ficoll,
pubmed-meshheading:7019373-Guinea Pigs,
pubmed-meshheading:7019373-Haptens,
pubmed-meshheading:7019373-Hemolytic Plaque Technique,
pubmed-meshheading:7019373-Immune Sera,
pubmed-meshheading:7019373-Immunoglobulin Idiotypes,
pubmed-meshheading:7019373-Immunosuppression,
pubmed-meshheading:7019373-Male,
pubmed-meshheading:7019373-Mice,
pubmed-meshheading:7019373-Mice, Inbred BALB C,
pubmed-meshheading:7019373-Mice, Inbred C57BL,
pubmed-meshheading:7019373-Mice, Inbred CBA,
pubmed-meshheading:7019373-Mice, Nude,
pubmed-meshheading:7019373-Nitrophenols,
pubmed-meshheading:7019373-Peptides,
pubmed-meshheading:7019373-Phenylacetates,
pubmed-meshheading:7019373-Rabbits,
pubmed-meshheading:7019373-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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