Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1981-3-17
|
pubmed:abstractText |
It has been shown that five alkylnitrites are mutagens by the Salmonella/microsome assay. n-Propyl-, n-butyl, iso-butyl and amyl-nitrite are direct mutagens on TA 1535; sec-butyl-nitrite is mutagen on TA 1535 only following metabolic activation by Aroclor-induced rat liver homogenate. Because of the known correlation between mutagenicity and carcinogenicity, we believe that amyl-nitrite and iso-butyl-nitrite, which are used as human drugs, should be tested for carcinogenicity in animals; in the meanwhile, their use should be allowed only in emergencies.
|
pubmed:language |
ita
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0037-8771
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
56
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
816-20
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7004467-Animals,
pubmed-meshheading:7004467-Aroclors,
pubmed-meshheading:7004467-Biotransformation,
pubmed-meshheading:7004467-Dose-Response Relationship, Drug,
pubmed-meshheading:7004467-Microsomes, Liver,
pubmed-meshheading:7004467-Mutagenicity Tests,
pubmed-meshheading:7004467-Mutagens,
pubmed-meshheading:7004467-Nitrites,
pubmed-meshheading:7004467-Rats,
pubmed-meshheading:7004467-Salmonella typhimurium,
pubmed-meshheading:7004467-Structure-Activity Relationship
|
pubmed:year |
1980
|
pubmed:articleTitle |
[Mutagenicity of alkylnitrites in the Salmonella test].
|
pubmed:publicationType |
Journal Article,
English Abstract
|