Linked Life Data

6993967

Source:http://linkedlifedata.com/resource/pubmed/id/6993967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-9-23
pubmed:abstractText
The effect of PGI2, the principal metabolite of arachidonic acid in mammalian arterial and venous tissues, on renal function and renin secretion was investigated in anesthetized, hypophysectomized dogs undergoing a maximal water diuresis. PGI2 in a concentration of 0.04 microgram/kg/min significantly increased urine flow and urinary sodium and potassium excretion in the absence of changes in glomerular filtration rate or blood pressure. The fact that PCI2 significantly increased free water clearance and distal delivery of sodium and inhibited distal fractional rea0sorption of glomerular filtrate is suggestive of an effect on proximal as well as distal sites of the nephron. PGI2 increased renin secretion rates threefold. This promotion of renin release may have been caused by an increase of ion flux across the macula densa or by an increase in renal blood flow. On a molar basis, PGI2 is about 10 times more potent than PGE2 with regard to natriuresis, diuresis and renin release when studied under identical conditions. Thus, PCI2 may be the major prostaglandin involved in the regulation of salt and water excretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2766
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of prostacyclin (PGI2) on renal function and renin secretion in hypophysectomized dogs.
pubmed:publicationType
Journal Article