Linked Life Data

6985712

Source:http://linkedlifedata.com/resource/pubmed/id/6985712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5742
pubmed:dateCreated
1980-2-26
pubmed:abstractText
Glucose is known to stimulate proinsulin synthesis in pancreatic islets of rats as well as of many other animals, but the mechanism involved remains uncertain. If proinsulin induction by glucose is regulated at the transcriptional level, the amount of proinsulin mRNA may be increased by the administration of glucose. Alternatively, if proinsulin induction is regulated at the translational level, the rate of proinsulin synthesis may not be correlated with the amount of proinsulin mRNA. We have now used a proinsulin cDNA hybridisation method to determine the amount of proinsulin mRNA and the subcellular distribuation of proinsulin mRNA in rat pancreatic islets. The results suggest that glucose-induced proinsulin synthesis is mainly achieved by enhancing the trnaslation efficiency of proinsulin mRNA preexistent on the membrane-bound polysome in pancreatic islets.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
283
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
100-2
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Translational control of proinsulin synthesis by glucose.
pubmed:publicationType
Journal Article