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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1983-1-7
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pubmed:abstractText |
We previously defined two T cell-derived lymphokines, BDCF mu and BCDF gama, which induce B cell differentiation in the absence of IL 2. Although these studies indicated that IL 2 was not required to induce Ig secretion, the effect of IL 2 on B cell differentiation was not established. In the present studies we have assessed the ability of purified IL 2 to induce IgM or IgG secretion. Our results demonstrate that IL 2 does not induce IgM secretion by BCL1 tumor cells, nor does it enhance BCDF mu-induced IgM secretion by these cells. Similarly, IL 2 had no effect on LPS or BCDF gamma-induced IgG secretion by normal B cells. Thus, we conclude that IL 2 does not act directly on B cells to induce differentiation.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2420-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6982922-Animals,
pubmed-meshheading:6982922-Antibody Formation,
pubmed-meshheading:6982922-B-Lymphocytes,
pubmed-meshheading:6982922-Cell Differentiation,
pubmed-meshheading:6982922-Female,
pubmed-meshheading:6982922-Immunoglobulin M,
pubmed-meshheading:6982922-Interleukin-2,
pubmed-meshheading:6982922-Lymphocyte Cooperation,
pubmed-meshheading:6982922-Lymphokines,
pubmed-meshheading:6982922-Mice,
pubmed-meshheading:6982922-Mice, Inbred Strains,
pubmed-meshheading:6982922-Monocytes,
pubmed-meshheading:6982922-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
Interleukin-2 does not induce murine B cells to secrete Ig.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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