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The lymphocytes infiltrating the liver of patients with tropical splenomegaly syndrome (TSS) were shown to be mainly T lymphocytes. Migration of leucocytes obtained from patients with TSS was inhibited by TSS liver extract, normal liver extract and liver-specific lipoprotein. These findings suggest that the hepatic infiltrates which occur in TSS are probably caused by a cell-mediated immune response to an antigen present in liver cells.
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