| pubmed-article:6980965 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:6980965 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6980965 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6980965 | pubmed:dateCreated | 1982-10-12 | lld:pubmed |
| pubmed-article:6980965 | pubmed:abstractText | Thymocytes and spleen cells from C57BL/6 mice (H-2b) neonatally tolerized to H-2k alloantigens do not generate an anti-vaccinia response restricted to H-2Kk when adoptively transferred to appropriate irradiated hosts. This is in sharp contrast to the case for negatively selected C57BL/6 spleen cells acutely depleted of alloreactivity. No evidence for suppression was found in cell mixture experiments. We have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 We now suggest that in the neonatally tolerized mouse, chronic, central delection of anti-H-2k clones during early T cell ontogeny eliminates the major source of cells able to give rise, via somatic mutation and expansion, to anti-H-2Kk + vaccinia specific cytotoxic T lymphocyte precursors (CTL-P) in the adult. A similar mechanism may operate in the (k + b) leads to b chimera; however, the presence of H-2kxb accessory and presenting cells may permit the eventual generation (via cross-stimulation) of an H-2k-restricted vaccinia-specific repertoire. This would account for our observation of such "aberrant recognition" CTL-P emerging in the spleens of older (k x b) leads to b chimeras. | lld:pubmed |
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| pubmed-article:6980965 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6980965 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980965 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6980965 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6980965 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6980965 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6980965 | pubmed:author | pubmed-author:DohertyP CPC | lld:pubmed |
| pubmed-article:6980965 | pubmed:author | pubmed-author:SchwartzD HDH | lld:pubmed |
| pubmed-article:6980965 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6980965 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6980965 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:6980965 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6980965 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6980965 | pubmed:pagination | 810-21 | lld:pubmed |
| pubmed-article:6980965 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6980965 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6980965 | pubmed:articleTitle | Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus. | lld:pubmed |
| pubmed-article:6980965 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6980965 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6980965 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6980965 | lld:pubmed |
