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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-10-12
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pubmed:abstractText |
Thymocytes and spleen cells from C57BL/6 mice (H-2b) neonatally tolerized to H-2k alloantigens do not generate an anti-vaccinia response restricted to H-2Kk when adoptively transferred to appropriate irradiated hosts. This is in sharp contrast to the case for negatively selected C57BL/6 spleen cells acutely depleted of alloreactivity. No evidence for suppression was found in cell mixture experiments. We have shown elsewhere that our neonatally tolerized animals have a centrally induced delection-type tolerance in the absence of obvious suppression.2 We now suggest that in the neonatally tolerized mouse, chronic, central delection of anti-H-2k clones during early T cell ontogeny eliminates the major source of cells able to give rise, via somatic mutation and expansion, to anti-H-2Kk + vaccinia specific cytotoxic T lymphocyte precursors (CTL-P) in the adult. A similar mechanism may operate in the (k + b) leads to b chimera; however, the presence of H-2kxb accessory and presenting cells may permit the eventual generation (via cross-stimulation) of an H-2k-restricted vaccinia-specific repertoire. This would account for our observation of such "aberrant recognition" CTL-P emerging in the spleens of older (k x b) leads to b chimeras.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-104413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-112841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-115003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-115959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-214510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-217013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-301550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-305460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-306404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-307186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-310857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-315984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-32648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-4275043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-4576586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6451027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6455666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-68474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6965398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6973594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6975310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6975326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6977774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-6981232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-7030924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-78955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-80023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980965-92183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
810-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6980965-Animals,
pubmed-meshheading:6980965-Antigens, Viral,
pubmed-meshheading:6980965-Chimera,
pubmed-meshheading:6980965-Cytotoxicity, Immunologic,
pubmed-meshheading:6980965-Female,
pubmed-meshheading:6980965-H-2 Antigens,
pubmed-meshheading:6980965-Immune Tolerance,
pubmed-meshheading:6980965-Isoantigens,
pubmed-meshheading:6980965-Male,
pubmed-meshheading:6980965-Mice,
pubmed-meshheading:6980965-Mice, Inbred C57BL,
pubmed-meshheading:6980965-Mice, Inbred Strains,
pubmed-meshheading:6980965-Models, Biological,
pubmed-meshheading:6980965-T-Lymphocytes,
pubmed-meshheading:6980965-Vaccinia virus
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pubmed:year |
1982
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pubmed:articleTitle |
Induction of neonatal tolerance to H-2k in B6 mice does not allow the emergence of T cells specific for H-2k plus vaccinia virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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