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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1982-9-17
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pubmed:abstractText |
The Ia+, H-2d BALB/c lymphoma cell line L10.A 2J was fused to T cell-depleted spleen cells from mouse strains bearing other H-2 haplotypes. A portion of the selected hybrids expressed Ia antigens of the normal spleen cell partner in the fusion as evidenced by their presentation of various antigens to a set of antigen-specific I-region-restricted T cell hybridomas. Three cloned hybrids were studied in detail. Antigen presentation was shown to be inhibited specifically by monoclonal anti-Ia antibodies. Both I-A and I-E molecules were expressed, including in the one case examined hybrid I-A and I-E molecules between the H-2d and H-2b haplotypes. These Ia+ B cell hybridomas provide a useful set of tools for studying the role of I-region-encoded molecules in antigen presentation to T cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-1095214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-310843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-567555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6034749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6153171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6153457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6158546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6158548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6170720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6173461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-621385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6460073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-6976995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-762493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980413-92524
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3604-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1982
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pubmed:articleTitle |
Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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