Linked Life Data

6977648

Source:http://linkedlifedata.com/resource/pubmed/id/6977648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-5-12
pubmed:abstractText
We examined the origin, nature and role of cellular defense mechanisms in experimental Haemophilus influenzae type b (Hib) meningitis in the infant rat using ultrastructural techniques. An extensive inflammatory exudate composed of granulocytes, lymphocytes and macrophages was observed on the leptomeninges of all animals with meningitis. At 1-3 days following Hib-inoculation, neutrophils were the major leukocytic element within the exudate while at 7-9 days the leukocyte population was dominated by macrophages. Irrespective of day of inoculation, leukocytes were observed undergoing diapedesis through the thin-walled blood vessels of the subarachnoid space and pial connective tissue, a phenomenon which suggested that the cellular elements composing the inflammatory exudate originated directly from the systemic circulation. Only neutrophils and macrophages demonstrated phagocytosis of free bacteria in the cerebrospinal fluid. The presence of plasma cells suggests that antibody to Hib may be synthesized locally within the subarachnoid space. Furthermore, cell-to-cell contacts among leukocytes may also contribute to the initiation and maintenance of the humoral immune response to Hib.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-4782
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
501-14
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Ultrastructural histopathology of experimental Haemophilus influenzae type B. Meningitis in the infant rat. I. Leukocytes of the spinal leptomeninges.
pubmed:publicationType
Journal Article