Linked Life Data

6973594

Source:http://linkedlifedata.com/resource/pubmed/id/6973594

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1981-10-25
pubmed:abstractText
The emergence of virus-specific cytotoxic T lymphocyte (CTL) precursors in thymus can be examined directly by stimulating thymocytes for 6 days in irradiated, virus-infected recipients. Responsiveness is a characteristic of the thymocytes themselves and does not reflect the presence of contaminating, blood-bourne T cells. Strong CTL activity may be generated earlier from thymus than from spleen or lymph node of lethally irradiated, bone marrow reconstituted mice. Also, the reconstitution of virus-immune CTL function in these peripheral lymphoid organs is thymus-dependent. Use of this simple experimental protocol offers considerable possibilities for the analysis of the role of the thymus in the ontogeny of the T cell repertoire.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0022-1759
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Thymocytes can be stimulated to give a strong vaccinia virus-immune cytotoxic T lymphocyte response.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.