Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1981-9-25
pubmed:abstractText
A special class of immunologic cells can lyse or damage a variety of target cells, notably malignant cells in vitro. These cells have been called natural killer (NK) cells because lysis does not require deliberate immunization by tumor cells. Although these cells can be distinguished from conventional T cells, B cells, and phagocytic cells, they have been difficult to define. We describe a representative cloned cell line that was obtained by cloning Ig -Ly-5+ cells from spleen. This clone, Cl.Ly-1-2-NK-1+/11, displays Thy-1, Ly-5, Qat-4, Qat-5 and NK-1 cell surface antigens and lyses the NK-sensitive YAC-1 lymphoma cells, but does not lyse RL-12 cells, an NK-resistant lymphoma. In addition, this clone lysed the P815 mastocytoma, EL4 lymphoma, and lipopolysaccharide-activated B lymphocyte targets. This cloned population therefore combined information for a unique display of cell surface antigens and specialized function similar to "activated" NK cells. Because this cloned population forms conjugates with susceptible but not resistant target cells, it may prove useful to identify the structure of cell surface molecules that recognize foreign cells. Finally, cells of this clone also specificity lysed target cells coated by antibodies to determinants on the target cell surface, demonstrating that a single cloned cell population can mediate two specialized immunologic functions: antibody-dependent cellular cytotoxicity and NK cell lysis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-103259, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-1080480, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-1086218, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-1159837, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-1234049, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-14207060, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-14400340, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-156241, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-187714, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-199846, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-307576, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-312902, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-330750, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-383877, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-4143189, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-448287, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-452109, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-4543318, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-4632629, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-479759, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-562478, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-566386, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-6154760, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-6156979, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-650155, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-6965957, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-6971154, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-705263, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-7354841, http://linkedlifedata.com/resource/pubmed/commentcorrection/6973001-761939
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1582-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Multiple activities of a cloned cell line mediating natural killer cell function.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.