Linked Life Data

6969088

Source:http://linkedlifedata.com/resource/pubmed/id/6969088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-2-26
pubmed:abstractText
Human epidermis from nickel sensitive patients was separated from dermis by means of a suction blister device and dissociated with trypsin. The epidermal cell suspensions obtained contained 3--5% Langerhans cells as judged by immunofluorescence staining of the cells with a rabbit anti-DR antiserum. The epidermal cells were co-cultured with purified autologous T lymphocytes with or without nickel sulphate. A strong proliferative T lymphocyte response to nickel sulphate was obtained provided epidermal cells were also present. Pretreatment of the epidermal cells with anti-DR antiserum abolished or greatly reduced the response. These data indicate that epidermal cells are able to present nickel sulphate to T lymphocytes in an immunogenic way. Since the responsible cells were DR antigen positive, it is highly probable that the cells responsible for these functions are the Langerhans cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-0963
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Studies on human epidermal Langerhans cells III. Induction of T lymphocyte response to nickel sulphate in sensitized individuals.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't