Linked Life Data

6968408

Source:http://linkedlifedata.com/resource/pubmed/id/6968408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5782
pubmed:dateCreated
1980-12-16
pubmed:abstractText
An immunosuppressive cyclic polypeptide, cyclosporin A (CyA), isolated originally from two species of fungi, prolongs organ allograft survival in several species. However, virtually nothing is known about the pharmacokinetics of this substance and its mode of action in man. We have quantified the impact of CyA on T-dependent and T-independent immunoglobulin (Ig) synthesis of human blood leukocytes in vitro, and on the proliferating capacity of the interacting lymphoid cell populations--T cells, B cells, T mu and T gamma cells. CyA inhibited all responses at approximately equal concentrations. The blast cells rather than resting lymphocytes and/or Ig-synthesizing plasma cells were incapacitated by the drug. As the phagocytosis of accessory macrophages was inhibited only at a 100--1,000-fold higher drug concentration, we conclude that CyA has a relatively specific direct effect on human T and B blast cells in vitro.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
287
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
542-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Effect of cyclosporin A on T-dependent and T-independent immunoglobulin synthesis in vitro.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.