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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-7-9
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pubmed:abstractText |
Rat brain synaptosomes isolated on discontinuous Ficoll gradient carry out rapid net uptake of gamma-aminobutyric acid through a high-affinity system (Km = 6.25 microM; Vmax = 1.2 nmol/min per mg of protein). The uptake of the labeled neurotransmitter is dependent on sodium concentration and is abolished by addition of 40 microM veratridine or 0.5 mM 2,4-diaminobutyric acid. Homoexchange in this preparation accounts for less than 10% of the measured uptake of gamma-amino[14C]butyric acid. It is concluded that the high-affinity transport exhibits properties characteristic of a system that is responsible for the rapid removal of gamma-aminobutyric acid from the synaptic cleft after neuronal transmission.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-1127436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-1156449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-13718948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-14336230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-25483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4129955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4153352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4154974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4355732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4397129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4724323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-4966292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-520553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-6031164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-6246202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-6247445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-670969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-728799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-7378733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-743245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-782192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-839440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6940139-991959
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1242-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1981
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pubmed:articleTitle |
Net uptake of gamma-aminobutyric acid by a high-affinity system of rat brain synaptosomes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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