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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1981-6-13
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pubmed:abstractText |
We interpreted our previous findings obtained with clonidine in depressive patients to indicate that in endogenous depressive patients--in contrast to neurotic depressive patients and controls--there is a reduced sensitivity of postsynaptic alpha-adrenergic receptors or of structures related to them. In the present study, after desipramine (DMI) (75 mg i.m.), endogenous depressives show a significantly reduced growth hormone (HGH) response as compared to neurotic depressive patients and to controls. The HGH response to DMI can be blocked by pretreatment with the alpha-blocker phentolamine (30 and 60 mg i.v.). Therefore we assume that in the DMI test, postsynaptic alpha-receptors are involved, thus giving further evidence for the importance of postsynaptic alpha-receptors in depression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0065-1591
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-6
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pubmed:dateRevised |
2008-2-15
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pubmed:meshHeading | |
pubmed:year |
1981
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pubmed:articleTitle |
Growth hormone response in patients with depression.
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pubmed:publicationType |
Journal Article
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