Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-6-13
pubmed:abstractText
We interpreted our previous findings obtained with clonidine in depressive patients to indicate that in endogenous depressive patients--in contrast to neurotic depressive patients and controls--there is a reduced sensitivity of postsynaptic alpha-adrenergic receptors or of structures related to them. In the present study, after desipramine (DMI) (75 mg i.m.), endogenous depressives show a significantly reduced growth hormone (HGH) response as compared to neurotic depressive patients and to controls. The HGH response to DMI can be blocked by pretreatment with the alpha-blocker phentolamine (30 and 60 mg i.v.). Therefore we assume that in the DMI test, postsynaptic alpha-receptors are involved, thus giving further evidence for the importance of postsynaptic alpha-receptors in depression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1591
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-6
pubmed:dateRevised
2008-2-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Growth hormone response in patients with depression.
pubmed:publicationType
Journal Article