| pubmed-article:6927126 | pubmed:abstractText | Gentamicin (G) disposition in six children with stable chronic renal failure (CRF) and in nine children with normal renal function (NRF) was determined by pharmacokinetic analysis of serum G concentration versus time data obtained over an 8-hour period following the administration of an intravenous loading dose. ES-TRIP curve fitting indicated that G disposition was best described by a biexponential function; however, a one-compartment open model also suitably characterized G disposition for an 8-hour period. Peak serum G concentrations were similar between the CRF and NRF groups, but concentrations were significantly different (P less than 0.005) at 8 hours following the loading dose. Also, significant differences (P less than 0.001) were found between the two groups for beta, t1/2 beta, plasma clearance, and k10. The relationship of creatinine clearance (Clcr) versus beta, described by the equation beta = 0.033 + 0.003 X Clcr (P less than 0.005, r = 0.97) permitted the best prediction of the G elimination constant from a parameter of renal function. This relationship remained linear over a broad range of Clcr values in our patients and in other previously reported children with CRF and NRF. | lld:pubmed |
