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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1982-1-28
|
| pubmed:abstractText |
Intraluminal pressure studies on patients with congenital aganglionosis showed that the aganglionic rectum contracted in an uncoordinated manner and failed to relax. Histochemical assessment of the innervation helped to explain the variable severity of the symptoms in this condition. It is concluded that (1) absence of ganglia prevents normal coordinated peristalsis and creates an obstructive element; (2) absence of reflex relaxation adds to the obstruction; (3) the degree of uncoordinated motor activity in distal aganglionic bowel probably relates to the number of cholinesterase-positive nerves in the circular muscle and adds another variable obstructive element; and (4) deficient innervation of distal ganglionic bowel probably creates a poor propulsive force and so accentuates more distal obstructive factors. Neurohistochemical and functional studies in the anorectum of cats reveal a somewhat different innervation pattern from that in humans but show that sphincteric tone is mainly due to alpha-adrenergic neural activity. Reflex relaxation of the internal anal sphincter is a complex function in which inhibitory responses override motor responses, and it involves an important non-adrenergic non-cholinergic component. The role of cholinergic nerves in the sphincter remains uncertain. Neurohistochemical assessment of full thickness biopsy specimens of rectal muscle from patients with disabling constipation shows that developmental neuronal dysplasias of the hind-gut may be divided into three main categories: (1) aganglionosis (Hirschsprung's disease), (2) hypoganglionosis and (3) hyperganglionosis, and that the different neuronal elements may be affected to differing degrees in individuals within each group. Resection of the aganglionic bowel is required in congenital aganglionosis but the combined diagnostic-therapeutic procedure of anorectal myotomy has been found beneficial in patients with hypoganglionosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-5208
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
83
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
326-54
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:6913488-Animals,
pubmed-meshheading:6913488-Cats,
pubmed-meshheading:6913488-Child, Preschool,
pubmed-meshheading:6913488-Cholinesterases,
pubmed-meshheading:6913488-Colon,
pubmed-meshheading:6913488-Constipation,
pubmed-meshheading:6913488-Disease Models, Animal,
pubmed-meshheading:6913488-Female,
pubmed-meshheading:6913488-Ganglia, Parasympathetic,
pubmed-meshheading:6913488-Humans,
pubmed-meshheading:6913488-Megacolon,
pubmed-meshheading:6913488-Myenteric Plexus,
pubmed-meshheading:6913488-Neurons,
pubmed-meshheading:6913488-Rectum
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
Myenteric plexus of the hind-gut: developmental abnormalities in humans and experimental studies.
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| pubmed:publicationType |
Journal Article
|