Linked Life Data

6884293

Source:http://linkedlifedata.com/resource/pubmed/id/6884293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-10-8
pubmed:abstractText
The response of human and bovine peripheral blood lymphocytes to PHA stimulation was measured in the presence of low concentrations of sodium arsenite and sodium arsenate. In bovine lymphocytes, 41% augmentation of the response occurred at 10(-6) M arsenite with a return to the normal response at 2.5 X 10(-6) M. Complete inhibition of mitogenesis occurred at 6 X 10(-6) M. In the presence of sodium arsenate, similar results were obtained but at the higher concentrations of 2 X 10(-5) (for 57% augmentation), 5.2 X 10(-5), and 1.9 X 10(-4) M, respectively. The possible significance of these findings in view of the known relationship between chronic arsenicalism and human skin cancer is discussed. It is suggested that arsenic compounds may, by potentiating mitogenesis, increase the possibility of errors in DNA replication, some of which could be potentially carcinogenic. Additionally, interference with the immune response could enable potentially cancerous cells to escape immune surveillance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The effects of arsenic compounds on human and bovine lymphocyte mitogenesis in vitro.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't