Linked Life Data

6882910

Source:http://linkedlifedata.com/resource/pubmed/id/6882910

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1983-10-8
pubmed:abstractText
The possibility of raising the efficacy of the treatment with lethal doses of 5-fluorouracil (FU) under body protection by allopurinol has been demonstrated in experimental blast leukemia (hemoblastosis) La. The protective effect was found to be dependent on dose-time correlations between FU and allopurinol. Oral administration of allopurinol in high doses of 150-200 mg/kg 30 minutes before intraperitoneal injection of FU provoked the development of CNS toxic lesions and death of part of mice in the next 72 hours. The data obtained provide evidence in favour of trying the efficacy of combined allopurinol and FU for non-lymphoid leukemias of man.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
84-6
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Protective effect of allopurinol during chemotherapy with 5-fluorouracil of mouse blast leukemia].
pubmed:publicationType
Journal Article, English Abstract