Linked Life Data

6880786

Source:http://linkedlifedata.com/resource/pubmed/id/6880786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1983-9-20
pubmed:abstractText
The author argues that the standard practice of determining an LD50 with 95% confidence limits is a waste of animals since the extra statistical precision is undermined by numerous other factors. For example, the LD50 of a given chemical often varies by at least 10-fold between different animal species and strains. Also, environmental factors can result in substantial differences in the LD50 of a given chemical in a given animal strain. Therefore, the use of this measure as a general index of toxicity, as a guide to further pharmacological or toxicological studies, or as a guide to human toxicity involves unnecessary and needless taking of animal life. These points will be amplified and substantiated by actual examples. Finally, the author will make some suggestions as to what could constitute a satisfactory acute animal test given current scientific and regulatory needs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0001-6683
pubmed:author
pubmed:issnType
Print
pubmed:volume
52 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-64
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Shortcomings of LD50-values and acute toxicity testing in animals.
pubmed:publicationType
Journal Article