Linked Life Data

6880556

Source:http://linkedlifedata.com/resource/pubmed/id/6880556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-9-9
pubmed:abstractText
The role of histamine H1 and H2 receptors in acute gastric ulceration was studied using a rat restraint-stress model. Cimetidine, an H2 receptor antagonist, afforded some protection at all doses. A dose response study showed that the mean number of ulcers per rat decreased exponentially with increased doses, and the proportion of animals protected from any ulceration increased in a simple linear progression. A dose of cimetidine was chosen which gave only partial protection from ulceration, and to this was added chlorpheniramine, an H1 antagonist. H1 antagonism alone was found to give partial protection, but when both H1 and H2 blocker were given a synergistic effect was seen thus indicating that H1 receptors do have a role in acute gastric ulceration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5482
pubmed:author
pubmed:issnType
Print
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-202
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Synergistic action of cimetidine and chlorpheniramine in prevention of restraint stress gastric ulceration in rats.
pubmed:publicationType
Journal Article