Linked Life Data

6873211

Source:http://linkedlifedata.com/resource/pubmed/id/6873211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-9-23
pubmed:abstractText
The duration of hexobarbital hypnosis was determined for individual male CFN rats at three month intervals over their total adult lifespan. The mean duration of hexobarbital hypnosis for the cohort linearly with advancing age. However, the sleeptimes for individual rats fell into one of four categories (gradual increase, terminal step increase, no change, or not possible to assign) when assigned as a function of duration of response to the barbiturate over the lifespan of the animals. These results suggest that the generally well-accepted increase in duration of drug response in aging animals is neither a ubiquitous nor concomitant feature of aging. Furthermore, the varying results obtained for individual animals in this longitudinal study point out the possible error which may be attendant when utilizing pooled tissue extracts to examine hepatic monooxygenase activity in vitro in senescent rodents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A longitudinal study of the relationship between aging and the duration of hexobarbital hypnosis in male CFN rats.
pubmed:publicationType
Journal Article, Comparative Study