Linked Life Data

6871849

Source:http://linkedlifedata.com/resource/pubmed/id/6871849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1983-9-23
pubmed:abstractText
The effect of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazine-induced colon cancer in rats was studied. Weanling Sprague-Dawley rats were fed semipurified diets containing 24% beef fat, 24% corn oil, 24% Crisco, or the three fats in equal parts to make a total of 5% fat with other macronutrients and micronutrients adjusted to balance the ratios of nutrient to calorie. After 4 weeks of dietary treatment, all rats, except vehicle-treated animals, received 1,2-dimethylhydrazine (15 mg/kg) by gavage, once a week for 5 weeks. The animals were fed the experimental diets until intestinal tumors developed, and surviving animals were sacrificed at 60 weeks. There was no effect of any of the high-fat diets tested on intestinal tumor incidence, latency, size, or frequency. All groups contained the same proportion of adenomas (less than 3%) as well as adenocarcinomas classified as mucinous. In the group fed 24% Crisco, tumors occurred with greater frequency in the proximal section of the colon than in lower segments, but the distribution was approximately uniform in the other groups. Cumulative probability of death with colon carcinoma was lowest in the 24% Crisco group, but the other high-fat groups did not differ significantly from the 5% mixed fat group nor from one another.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4083-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effect of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.