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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1983-8-26
|
| pubmed:abstractText |
Mast cell-dependent late phase reactions (LPR) occur in rat skin and are characterized histologically by an early (1- to 8-hr) neutrophil-rich and later (8- to 24-hr) mononuclear cell-rich infiltrate. To extend previous observations on the role of the neutrophil in the sequential histologic development of cutaneous LPR, rats were selectively depleted of circulating neutrophils using rabbit anti-rat neutrophil antibody (anti-neut), and the effects of this treatment on the histologic intensity of LPR were analyzed. In addition, the effects of neutrophil depletion on cutaneous delayed-type hypersensitivity (DTH) reactions produced by immunization with Freund's complete adjuvant followed by intradermal challenge with purified protein derivative (PPD) were assessed. Following anti-neut treatment, cutaneous DTH reactions were unaffected. In contrast, selective neutrophil depletion resulted in significant reductions in the intensity of cutaneous LPR at both 6 to 8 and 24 hr following anti-IgE or rat mast cell granule injection. Further, statistical comparison of circulating neutrophil counts with the capacity of the animal to express LPR revealed a highly significant direct correlation. These data confirm the previous observations that rat LPR are neutrophil-dependent reactions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
929-33
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6863936-Agranulocytosis,
pubmed-meshheading:6863936-Animals,
pubmed-meshheading:6863936-Antibodies,
pubmed-meshheading:6863936-Hypersensitivity, Immediate,
pubmed-meshheading:6863936-Leukocyte Count,
pubmed-meshheading:6863936-Mast Cells,
pubmed-meshheading:6863936-Neutropenia,
pubmed-meshheading:6863936-Neutrophils,
pubmed-meshheading:6863936-Rabbits,
pubmed-meshheading:6863936-Rats,
pubmed-meshheading:6863936-Rats, Inbred Strains,
pubmed-meshheading:6863936-Time Factors,
pubmed-meshheading:6863936-Vinblastine
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
The biologic activity of mast cell granules. VII. The effect of anti-neutrophil antibody-induced neutropenia on rat cutaneous late phase reactions.
|
| pubmed:publicationType |
Journal Article
|