| pubmed-article:6863281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0025251 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0022634 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:6863281 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:6863281 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:6863281 | pubmed:dateCreated | 1983-8-17 | lld:pubmed |
| pubmed-article:6863281 | pubmed:abstractText | A plasma membrane-associated serine esterase (protease) has previously been reported to be required during stimulation of a variety of cell types. In this study we have examined the role of such a protease on membrane potential changes using an optical probe of membrane potential 3,3'-dipropylthiodicarbocyanine iodide. The irreversible chymotrypsin-like protease inhibitor TPCK (tosyl-L-phenylalanyl chloromethyl ketone) inhibited membrane potential changes in rat neutrophils in response to phorbol myristate acetate, N-formylmethionylleucylphenylalanine and the calcium ionophore A23187 in a time- and dose-dependent manner. This inhibition was correlated with the known inhibitory effects on superoxide (O-2) generation and enzyme release (lysozyme and beta-glucuronidase). High external calcium concentrations overcame the inhibitory effects of TPCK on A23187-induced stimulation but had no effect on the inhibition of N-formylmethionylleucylphenylalanine stimulation. These results suggest that a TPCK-inhibitable activity is required for the development of the membrane potential changes that are coupled to subsequent secretory events and precede a calcium requiring activity. | lld:pubmed |
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| pubmed-article:6863281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6863281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6863281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6863281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6863281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6863281 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6863281 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:6863281 | pubmed:author | pubmed-author:PhanS HSH | lld:pubmed |
| pubmed-article:6863281 | pubmed:author | pubmed-author:WardP APA | lld:pubmed |
| pubmed-article:6863281 | pubmed:author | pubmed-author:DurumS KSK | lld:pubmed |
| pubmed-article:6863281 | pubmed:author | pubmed-author:SulavikM CMC | lld:pubmed |
| pubmed-article:6863281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6863281 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:6863281 | pubmed:volume | 258 | lld:pubmed |
| pubmed-article:6863281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6863281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6863281 | pubmed:pagination | 8123-8 | lld:pubmed |
| pubmed-article:6863281 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6863281 | pubmed:meshHeading | pubmed-meshheading:6863281-... | lld:pubmed |
| pubmed-article:6863281 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6863281 | pubmed:articleTitle | Inhibition by tosyl-L-phenylalanyl chloromethyl ketone of membrane potential changes in rat neutrophils. Correlation with the inhibition of biological activity. | lld:pubmed |
| pubmed-article:6863281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6863281 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6863281 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6863281 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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