Linked Life Data

6863090

Source:http://linkedlifedata.com/resource/pubmed/id/6863090

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-8-11
pubmed:abstractText
We applied the arterial and venous occlusion technique in an in situ, isolated left lower lobe preparation of a dog lung to compare the effects of hypoxia with the effects of airway pressure elevation, and the infusion of serotonin, norepinephrine, and histamine. The total arteriovenous pressure drop across the lobe was partitioned longitudinally into pressure drops across the relatively indistensible arteries (delta Pa) and veins (delta Pv) and across the middle distensible vessels (delta Pm). Hypoxia increased primarily delta Pm, as did elevation of airway pressure, whereas the vasoactive drugs increased either delta Pa or delta Pv. The increases in pulmonary arterial pressure (Pa) caused by hypoxia and by elevation of airway pressure were independent of blood flow rate, but increases in Pa induced by the vasoactive drugs were dependent on flow rate. We conclude that in the dog hypoxia acts primarily on small distensible vessels, whereas pulmonary vasoactive drugs constrict the relatively indistensible arteries and veins. It is possible that the increase in pulmonary vascular resistance during hypoxia did not involve smooth muscle contraction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1298-302
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Site of pulmonary hypoxic vasoconstriction studied with arterial and venous occlusion.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't