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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1983-7-29
|
| pubmed:abstractText |
A 3-stage, concentration-maintaining intravenous infusion regimen of pirmenol, a new antiarrhythmic agent, was tested for efficacy and safety in 8 subjects with chronic, stable premature ventricular beats. The regimen, which consisted of (1) a priming bolus of 50 mg over 2 minutes, followed by (2) a rapid loading infusion of 2.5 mg/min for 1 hour, and (3) a maintenance infusion of 0.25 mg/min, rapidly achieved and maintained stable plasma pirmenol levels from 0.94 to 2.75 micrograms/ml, during infusions lasting up to 48 hours. Therapeutic efficacy was evaluated during 4-hour infusions in 5 patients utilizing a randomized, double-blind, placebo-controlled study design. Pirmenol suppressed average premature ventricular beat frequency 93 +/- 6% compared with control values (p = 0.03). Pirmenol infusions were unassociated with toxicity. There were slight but significant increases in diastolic blood pressure, QRS duration, and corrected Q-T interval. No significant changes occurred in systolic blood pressure, heart rate, P-R interval, or laboratory variables. Pirmenol is a promising therapeutic agent that warrants further evaluation. The 3-stage infusion satisfactorily achieves and maintains therapeutic plasma pirmenol levels.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
83-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6858934-Adult,
pubmed-meshheading:6858934-Aged,
pubmed-meshheading:6858934-Anti-Arrhythmia Agents,
pubmed-meshheading:6858934-Arrhythmias, Cardiac,
pubmed-meshheading:6858934-Blood Pressure,
pubmed-meshheading:6858934-Double-Blind Method,
pubmed-meshheading:6858934-Drug Evaluation,
pubmed-meshheading:6858934-Electrocardiography,
pubmed-meshheading:6858934-Female,
pubmed-meshheading:6858934-Heart Rate,
pubmed-meshheading:6858934-Humans,
pubmed-meshheading:6858934-Infusions, Parenteral,
pubmed-meshheading:6858934-Kinetics,
pubmed-meshheading:6858934-Male,
pubmed-meshheading:6858934-Middle Aged,
pubmed-meshheading:6858934-Monitoring, Physiologic,
pubmed-meshheading:6858934-Piperidines,
pubmed-meshheading:6858934-Random Allocation
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Efficacy, safety, and pharmacokinetics of a concentration-maintaining regimen of intravenous pirmenol.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|