Linked Life Data

6855235

Source:http://linkedlifedata.com/resource/pubmed/id/6855235

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-7-8
pubmed:abstractText
We studied the effects of estrogen administration in the anterior pituitary gland (APG) of male rats. The subcellular distribution of estradiol receptors, and some biological responses, such as prolactin secretion and progestine receptors were examined. In the presence of circulating estrogens, the binding of [3H]-estradiol decreased in the cytosol and increased in nuclei. The total binding augmented significantly (P less than 0.05). These changes were dose and time dependent. So, in long chronic treatment, the changes in subcellular receptor distribution were greater, in accordance with higher serum estrogen level. Serum prolactin concentration and progestin receptor in the APG increased continuously as a function of time of the estrogen treatment. They were related to the presence of nuclear estradiol receptors, which remained elevated throughout the entire experimental period.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-4731
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
The influence of estrogen administration on the subcellular receptors distribution and its biological effect in the rat anterior pituitary gland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't