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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1983-7-8
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pubmed:abstractText |
The title compounds were designed as flexible congeners of trans-octahydrobenz[h]isoquinoline, in which the dopamine moiety can exist in the alpha conformation. Extremely low dopamine-like effects in the title series in the cat cardioaccelerator nerve assay paralleled low activity in the trans-octahydrobenz[h]isoquinoline compounds and was consistent with a prior proposal of the presence of a bulky region on the dopamine receptor(s).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6854584-Animals,
pubmed-meshheading:6854584-Apomorphine,
pubmed-meshheading:6854584-Blood Pressure,
pubmed-meshheading:6854584-Cats,
pubmed-meshheading:6854584-Dopamine,
pubmed-meshheading:6854584-Female,
pubmed-meshheading:6854584-Haloperidol,
pubmed-meshheading:6854584-Heart Rate,
pubmed-meshheading:6854584-Male,
pubmed-meshheading:6854584-Naphthalenes,
pubmed-meshheading:6854584-Propranolol,
pubmed-meshheading:6854584-Receptors, Dopamine,
pubmed-meshheading:6854584-Stimulation, Chemical,
pubmed-meshheading:6854584-Tetrahydronaphthalenes
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pubmed:year |
1983
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pubmed:articleTitle |
1-(Aminomethyl)-6,7-dihydroxytetralin derivatives: synthesis and assessment of dopamine-like effects.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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