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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1983-7-15
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pubmed:abstractText |
Human skeletal muscle acetylcholine receptor (AChR) antibodies were assayed by a double immunoprecipitation technique using 125I-alpha-bungarotoxin as the label. Monkey AChRs were found to be superior to those from diabetic humans for analytical and practical reasons. The analytical sensitivity is 0.05 nmol alpha-bungarotoxin/L serum. The between-run and within-run precision (1 c.v.) of the assay are 13% and 3%, respectively. The normal range is 0-0.2 nmol alpha-bungarotoxin/L. There was no correlation between the antibody concentration and the clinical severity of myasthenia gravis. The clinical sensitivity and specificity of the assay for generalized myasthenia gravis are 79% and 96%, and for ocular myasthenia gravis 29% and 96%, respectively.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0009-9120
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6851078-Animals,
pubmed-meshheading:6851078-Autoantibodies,
pubmed-meshheading:6851078-Bungarotoxins,
pubmed-meshheading:6851078-Female,
pubmed-meshheading:6851078-Humans,
pubmed-meshheading:6851078-Macaca fascicularis,
pubmed-meshheading:6851078-Male,
pubmed-meshheading:6851078-Muscles,
pubmed-meshheading:6851078-Myasthenia Gravis,
pubmed-meshheading:6851078-Receptors, Cholinergic
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pubmed:year |
1983
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pubmed:articleTitle |
Measurement of human skeletal muscle acetylcholine receptor antibodies using monkey receptors.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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