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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
A gas chromatographic procedure was developed to determine free and conjugated cis-3,3,5-trimethylcylcohexanol in plasma and urine. The sample is extracted with dichloromethane when free cis-3,3,5-trimethylcyclohexanol is determined, or with hexane after enzymatic hydrolysis, when conjugated cis-3,3,5-trimethylcyclohexanol is determined. An aliquot of the organic extract is injected into a stainless-steel column (packed with Carbowax 20M, 15% on Chromosorb W AW 100-120 mesh) and detected with a flame ionization detector. Extraction recovery from plasma and urine was almost 100% and the limit of quantification was fixed at 100 ng/ml plasma or urine. The procedure was evaluated in a pharmacokinetic study of cyclandelate and its metabolite cis-3,3,5-trimethylcyclohexanol.
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9673
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-305
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6833426-Animals,
pubmed-meshheading:6833426-Biotransformation,
pubmed-meshheading:6833426-Cyclandelate,
pubmed-meshheading:6833426-Cyclohexanols,
pubmed-meshheading:6833426-Flame Ionization,
pubmed-meshheading:6833426-Isomerism,
pubmed-meshheading:6833426-Kinetics,
pubmed-meshheading:6833426-Rabbits
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pubmed:year |
1983
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pubmed:articleTitle |
[Determination of free and conjugated cis-3,3,5-trimethylcyclohexanol in plasma and urine].
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pubmed:publicationType |
Journal Article,
English Abstract
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