Linked Life Data

6819011

Source:http://linkedlifedata.com/resource/pubmed/id/6819011

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-4-15
pubmed:abstractText
We wished to determine if congenitally athymic nude male mice have the same reduction in circulating concentrations of gonadotropins and gonadal steroids observed in their female counterparts when compared to their normal heterozygous littermates. We therefore quantitated pituitary and circulating concentrations of gonadotropins and circulating levels of testosterone in 102 congenitally athymic mice and 101 of their heterozygous littermates ranging in age from 1 to 120 days. Although the developmental patterns observed for both circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were similar to those previously observed in rats and mice, the athymic mice had significantly reduced concentrations of both pituitary and serum LH and FSH in comparison to the heterozygotes. In general, the reduced secretion of gonadotropins was most marked prior to sexual maturation but persisted in adult athymic males. Circulating concentrations of testosterone were also markedly reduced in the adult athymic males. Histologically, the number of Leydig cells appeared reduced in testes from 20-day-old athymic mice. However, no differences could be detected in testes from 40-day-old animals, and spermatogenesis appeared normal. Thus, unlike athymic females, athymic male mice appear to have normal reproductive capacity despite these hormonal abnormalities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1267-76
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Hormonal basis of reproductive defects in athymic mice: reduced gonadotropins and testosterone in males.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.