6818244

Source:http://linkedlifedata.com/resource/pubmed/id/6818244

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002556, umls-concept:C0033809, umls-concept:C0039593, umls-concept:C0079240, umls-concept:C0686904, umls-concept:C1705117
pubmed:issue	4
pubmed:dateCreated	1983-3-11
pubmed:abstractText	The use of dilutions differing by small arithmetic increments was studied as a means for improving the definition and measurement of minimum inhibitory concentrations and precision parameters for testing Pseudomonas aeruginosa versus the aminoglycosides by the broth microdilution test. For five strains of P. aeruginosa versus gentamicin, tobramycin, and amikacin, comparisons were made of minimum inhibitory concentrations which were replicated in parallel by using three microdilution systems: small increment panels prepared by us, modified twofold dilution panels prepared by us, and similar modified twofold dilution panels obtained commercially. The small increment dilutions were prepared to differ by concentrations of 1.0 microgram/ml for gentamicin and tobramycin and by 2.0 micrograms/ml for amikacin. Use of the small increment dilutions resulted in the ability to measure minimum inhibitory concentrations at more closely spaced intervals than those dictated by modified twofold dilution schemes, and confidence limits were significantly improved. The average coefficient of variation for the small increment microdilution test results was 9.5%, with 99.5% of minimum inhibitory concentrations falling within +/- 2 small increment dilutions from their modal values.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-101077, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-101130, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-116543, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-4370727, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6762709, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6766293, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6779623, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6784569, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6784571, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-6787072, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-717929, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-7355388, http://linkedlifedata.com/resource/pubmed/commentcorrection/6818244-7380766
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505564
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Aminoglycosides, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0095-1137
pubmed:author	pubmed-author:FoxJ MJM, pubmed-author:LallyR TRT, pubmed-author:QuallC OCO, pubmed-author:WoolfreyB FBF
pubmed:issnType	Print
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	663-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:6818244-Aminoglycosides, pubmed-meshheading:6818244-Anti-Bacterial Agents, pubmed-meshheading:6818244-Microbial Sensitivity Tests, pubmed-meshheading:6818244-Pseudomonas aeruginosa
pubmed:year	1982
pubmed:articleTitle	Broth microdilution testing of Pseudomonas aeruginosa and aminoglycosides: need for employing dilutions differing by small arithmetic increments.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't