| pubmed-article:6809623 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0305065 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0020861 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0369247 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0065944 | lld:lifeskim |
| pubmed-article:6809623 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:6809623 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6809623 | pubmed:dateCreated | 1982-10-29 | lld:pubmed |
| pubmed-article:6809623 | pubmed:abstractText | The nature and kinetics of the serum antibody response to pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates were studied in mice. Bovine serum albumin and diphtheria and tetanus toxoids were used as carrier proteins. The purified polysaccharides induced only immunoglobulin M (IgM) antibodies in thymus-bearing as well as congenic athymic (nude) mice. The polysaccharides covalently conjugated to proteins produced IgM and IgG antibodies in normal mice, but only IgM antibodies in nude mice. A second dose of the polysaccharide-protein conjugates resulted in a booster effect in the IgG response to the polysaccharides. Moreover, memory B-cells, generated after a primary injection with the polysaccharide-protein conjugates, could be triggered to the production of IgG antibodies after a second injection with the pure polysaccharides alone. These data indicate that the antibody response to the pure polysaccharides is thymus independent and that this response can be changed into a thymus-dependent response by covalent conjugation of the polysaccharide to a thymus-dependent protein. | lld:pubmed |
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| pubmed-article:6809623 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6809623 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6809623 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6809623 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6809623 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:6809623 | pubmed:author | pubmed-author:BeuveryE CEC | lld:pubmed |
| pubmed-article:6809623 | pubmed:author | pubmed-author:van RossumFF | lld:pubmed |
| pubmed-article:6809623 | pubmed:author | pubmed-author:NagelJJ | lld:pubmed |
| pubmed-article:6809623 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6809623 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:6809623 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6809623 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6809623 | pubmed:pagination | 15-22 | lld:pubmed |
| pubmed-article:6809623 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6809623 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6809623 | pubmed:articleTitle | Comparison of the induction of immunoglobulin M and G antibodies in mice with purified pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates. | lld:pubmed |
| pubmed-article:6809623 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6809623 | pubmed:publicationType | Comparative Study | lld:pubmed |
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