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rdf:type |
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lifeskim:mentions |
umls-concept:C0020861,
umls-concept:C0026809,
umls-concept:C0033684,
umls-concept:C0065944,
umls-concept:C0205263,
umls-concept:C0301869,
umls-concept:C0305065,
umls-concept:C0332307,
umls-concept:C0369247,
umls-concept:C1707455,
umls-concept:C1998793
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pubmed:issue |
1
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pubmed:dateCreated |
1982-10-29
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pubmed:abstractText |
The nature and kinetics of the serum antibody response to pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates were studied in mice. Bovine serum albumin and diphtheria and tetanus toxoids were used as carrier proteins. The purified polysaccharides induced only immunoglobulin M (IgM) antibodies in thymus-bearing as well as congenic athymic (nude) mice. The polysaccharides covalently conjugated to proteins produced IgM and IgG antibodies in normal mice, but only IgM antibodies in nude mice. A second dose of the polysaccharide-protein conjugates resulted in a booster effect in the IgG response to the polysaccharides. Moreover, memory B-cells, generated after a primary injection with the polysaccharide-protein conjugates, could be triggered to the production of IgG antibodies after a second injection with the pure polysaccharides alone. These data indicate that the antibody response to the pure polysaccharides is thymus independent and that this response can be changed into a thymus-dependent response by covalent conjugation of the polysaccharide to a thymus-dependent protein.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-1086861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-1096382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-1254975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-13436486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-13851710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-14171526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-1445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-16560537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-22439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-234300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-240888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-31985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-351058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-3609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-372096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-389782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4138070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4154347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4391281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4396488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4443551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-4598645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-6790606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-68986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-6967514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-7000684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-7185955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6809623-869171
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6809623-Animals,
pubmed-meshheading:6809623-Antibodies, Bacterial,
pubmed-meshheading:6809623-B-Lymphocytes,
pubmed-meshheading:6809623-Diphtheria Toxoid,
pubmed-meshheading:6809623-Immunoglobulin G,
pubmed-meshheading:6809623-Immunoglobulin M,
pubmed-meshheading:6809623-Mice,
pubmed-meshheading:6809623-Mice, Nude,
pubmed-meshheading:6809623-Neisseria meningitidis,
pubmed-meshheading:6809623-Polysaccharides, Bacterial,
pubmed-meshheading:6809623-Serum Albumin, Bovine,
pubmed-meshheading:6809623-Streptococcus pneumoniae,
pubmed-meshheading:6809623-T-Lymphocytes,
pubmed-meshheading:6809623-Tetanus Toxoid
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pubmed:year |
1982
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pubmed:articleTitle |
Comparison of the induction of immunoglobulin M and G antibodies in mice with purified pneumococcal type 3 and meningococcal group C polysaccharides and their protein conjugates.
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pubmed:publicationType |
Journal Article,
Comparative Study
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