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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1982-5-12
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pubmed:abstractText |
Blood kinetics of 1-naphthyl-N-methyl[14C] carbamate were determined after intravenous injection in DMSO, and after intragastric and intraduodenal administration in DMSO, oil, gum tragacanth and milk. The acetylcholinesterase inhibition and the level of 14C-activity were both determined in the blood over various periods of time. The values of the absorption rate constants after intragastric and intraduodenal administration were found to be: 0.5 h(-1) and 7 h(-1) with DMSO, 0.6 h(-1) and 0.42 h(-1) with oil, 0.13 h(-1) and 0.22 h (-1) with gum tragacanth and 0.10 h(-1) with milk. Appearance of the toxic effect (the inhibition of the acetylcholinesterases) was closely related to the absorption rate constants which themselves depend on the administration vehicle employed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-483X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-51
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6801818-Animals,
pubmed-meshheading:6801818-Carbaryl,
pubmed-meshheading:6801818-Dimethyl Sulfoxide,
pubmed-meshheading:6801818-Female,
pubmed-meshheading:6801818-Intestinal Absorption,
pubmed-meshheading:6801818-Kinetics,
pubmed-meshheading:6801818-Pharmaceutical Vehicles,
pubmed-meshheading:6801818-Rats
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pubmed:year |
1981
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pubmed:articleTitle |
Variations of the digestive absorption kinetics of carbaryl with the nature of the vehicle.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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