Linked Life Data

679403

Source:http://linkedlifedata.com/resource/pubmed/id/679403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1978-10-27
pubmed:abstractText
75Se-labeled selenite was used to study its metabolism by intact rat erythrocytes in vitro. Utilizing both N-ethylmaleimide and excess selenite to lower erythrocyte GSH concentrations it was shown that the uptake and subsequent metabolism of selenite was dependent upon GSH. The secondary release of Se by rat erythrocytes had no relation to the erythrocyte transport of GSSG. While fluoride depressed and chromate increased GSSG transport, chromate, a glutathione reductase inhibitor, decreased Se release. This was consistent with the concept that the release was secondary to a reaction catalyzed by gluthathione reductase. The similarity of the I50 values for chromates' irreversible inhibition of glutathione reductase and for the inhibition of Se release further suggested a relationship between these two events. These results supported the hypothesis that H2Se or a similar product of GSSeSG reduction by glutathione reductase was the final product of selenite metabolism by rat erythrocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-2797
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-313
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
The metabolism of selenite by intact rat erythrocytes in vitro.
pubmed:publicationType
Journal Article, In Vitro