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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1981-8-20
|
| pubmed:abstractText |
A sensitive viscosimetric approach for measuring DNA single-strand breaks induced by low doses of alkylating agents is presented. The assay is based on the breaks-induced increasing rate of strand separation of rat liver DNA in alkaline solution (pH 12,5; 22 C). Because of the strong dependence of viscosity on DNA unwinding, measurement of time-course of viscosity increase can be used to detect small breakage of DNA. The kinetics of DNA denaturation has been also studied under two different alkaline conditions.
|
| pubmed:language |
ita
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0037-8771
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
414-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6786309-Alkylating Agents,
pubmed-meshheading:6786309-Animals,
pubmed-meshheading:6786309-Cell Nucleus,
pubmed-meshheading:6786309-DNA, Single-Stranded,
pubmed-meshheading:6786309-Glycine,
pubmed-meshheading:6786309-Liver,
pubmed-meshheading:6786309-Male,
pubmed-meshheading:6786309-Rats,
pubmed-meshheading:6786309-Viscosity
|
| pubmed:year |
1981
|
| pubmed:articleTitle |
[Viscosimetric evaluation of DNA fragmentation induced in vivo by alkylating agents].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|