| pubmed-article:6785086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C0004595 | lld:lifeskim |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C0597763 | lld:lifeskim |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:6785086 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6785086 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6785086 | pubmed:dateCreated | 1981-7-20 | lld:pubmed |
| pubmed-article:6785086 | pubmed:abstractText | We have analyzed a mutation of Bacillus subtilis (bfmB) that results in an acyl-CoA:acyl-carrier-protein transacylase with low affinity for branched acyl-CoA substrates; it maps in the acf-hisH region of the chromosome. The aceA mutation, present in the parent of the bfmB mutant, causes a deficiency in pyruvate dehydrogenase and maps in the pycA-pyrA region. Strains carrying the bfmB mutation synthesize branched-chain fatty acids at a rate sufficient for normal growth only if branched acyl-CoA precursors are present in the medium. They grow well if the medium is supplemented with 0.1 mM 2-methylbutyrate, isobutyrate or isovalerate, or with 1.0 mM isoleucine or valine; leucine does not support growth. Growth supported by valine and isoleucine is inhibited by butyrate and other straight short-chain fatty acids at concentrations (0.1 mM) which do not inhibit growth of the standard strain; the inhibition is prevented by short branched fatty acids which are converted to long-chain fatty acids appearing as activity of B. subtilis is controlled by separate enzymatic sites for the acyl-CoA precursors of branched and straight-chain fatty acids. Whether these sites are contained in one or two enzymes is not known. | lld:pubmed |
| pubmed-article:6785086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6785086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6785086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6785086 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6785086 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:6785086 | pubmed:author | pubmed-author:FreeseEE | lld:pubmed |
| pubmed-article:6785086 | pubmed:author | pubmed-author:IijimaTT | lld:pubmed |
| pubmed-article:6785086 | pubmed:author | pubmed-author:EisenstadtEE | lld:pubmed |
| pubmed-article:6785086 | pubmed:author | pubmed-author:BoudreauxD... | lld:pubmed |
| pubmed-article:6785086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6785086 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:6785086 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:6785086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6785086 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6785086 | pubmed:pagination | 175-81 | lld:pubmed |
| pubmed-article:6785086 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
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| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:meshHeading | pubmed-meshheading:6785086-... | lld:pubmed |
| pubmed-article:6785086 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6785086 | pubmed:articleTitle | Biochemical and genetic characterization of an auxotroph of Bacillus subtilis altered in the Acyl-CoA:acyl-carrier-protein transacylase. | lld:pubmed |
| pubmed-article:6785086 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6785086 | lld:pubmed |
