|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1987-9-30
|
|
pubmed:abstractText |
The effect of acute and chronic cimetidine administration on glucose tolerance and insulin secretion was studied in healthy male volunteers. Cimetidine was administered intravenously (4 mg X kg-1 followed by 0.7 mg X kg-1 X h-1) in acute studies and by oral route (1 g/die for 4 weeks) in long-term studies. Oral (100 g) or intravenous (0.5 g X kg-1) glucose was used as a stimulus for insulin secretion in both studies. Neither acute nor chronic cimetidine administration modified insulin secretion and glucose tolerance. These data are consistent with the idea that H2-receptors are not involved in the insulinogenic effect of glucose.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0301-0163
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
228-36
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:6765588-Administration, Oral,
pubmed-meshheading:6765588-Adult,
pubmed-meshheading:6765588-Blood Glucose,
pubmed-meshheading:6765588-Cimetidine,
pubmed-meshheading:6765588-Drug Administration Schedule,
pubmed-meshheading:6765588-Glucose,
pubmed-meshheading:6765588-Glucose Tolerance Test,
pubmed-meshheading:6765588-Humans,
pubmed-meshheading:6765588-Injections, Intravenous,
pubmed-meshheading:6765588-Insulin,
pubmed-meshheading:6765588-Male,
pubmed-meshheading:6765588-Receptors, Histamine H2
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
Effect of acute and chronic cimetidine administration on glucose tolerance and insulin secretion in man.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
